On the cover: Cryptococcus neoformans is a deadly fungal pathogen whose intracellular lifestyle is important for virulence. In this issue, perform a global phosphoproteomic analysis of the host response to C. neoformans infection and identify numerous and diverse host proteins that are phosphorylated following fungal ingestion by macrophages. Among these, phosphorylation and activation of components of the host autophagy initiation complex confer susceptibility to fungal internalization and intracellular replication. The cover image presents an artistic rendition of a host cell internalizing C. neoformans with recruitment of host autophagy initiation proteins to the phagocytic cup. Art by Paul de Figueiredo.

Wippold JA, Wang H, Tingling J, Leibowitz JL, de Figueiredo P, Han A. PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology. Lab Chip. 2020 Mar 20. doi: 10.1039/c9lc01165j. PMID: 32196032.

Dadaneh SZ, de Figueiredo P, Sze S-H, Zhou M, and X. Qian. Bayesian Gamma-Negative Binomial Modeling of Single-Cell RNA Sequencing Data. ArXiv. 2019 arXiv:1908.00650. 1 August 2019.

Patrick KL, Wojcechowskyj JA, Bell SL, Riba MN, Jing T, Talmage S, Xu P, Cabello AL, Xu J, Shales M, Jimenez-Morales D, Ficht TA, de Figueiredo P, Samuel JE, Li P, Krogan NJ, Watson RO. Quantitative Yeast Genetic Interaction Profiling of Bacterial Effector Proteins Uncovers a Role for the Human Retromer in Salmonella Infection. Cell Systems. 2018 Sep 26;7(3):323-338 doi: 10.1016/j.cels.2018.06.010. Epub 2018 Aug 1. PMID: 30077634.

Pandey A, Lin F, Cabello AL, da Costa LF, Feng X, Feng HQ, Zhang MZ, Iwawaki T, Rice-Ficht A, Ficht TA, de Figueiredo P, Qin QM. Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis. Frontiers in Cellular and Infection Microbiology. 2018 Apr 20. doi: 10.3389/fcimb.2018.00103. PMID: 29732320.

Dickman M, Williams B, Li Y, de Figueiredo P, Wolpert T. Reassessing Plant Apoptosis. Nature Plants. 2017 Oct 16. doi: 10.1038/s41477-017-0045-1. PMID: 28947814.

Pandey A, Ding SL, Qin QM, Gupta R, Gomez G, Lin F, Feng X, Fachini da Costa L, Chaki SP, Katepalli M, Case ED, van Schaik EJ, Sidiq T, Khalaf O, Arenas A, Kobayashi KS, Samuel JE, Rivera GM, Alaniz RC, Sze SH, Qian X, Brown WJ, Rice-Ficht A, Russell WK, Ficht TA, de Figueiredo P. Global reprogramming of host kinase signaling in response to fungal infection. Cell Host & Microbe. 2017. May 10;21(5):637-649.e6. doi: 10.1016/j.chom.2017.04.008. PMID: 28494245

Mwangi W, de Figueiredo P, Criscitiello MF. One Health: Addressing Global Challenges at the Nexus of Human, Animal, and Environmental Health. PLoS Pathogens. 2016. Sep 15;12(9):e1005731. doi: 10.1371/journal.ppat.1005731. eCollection 2016 Sep. PMID: 27631500

Pandey A, Cabello A, Akoolo L, Rice-Ficht A, Arenas-Gamboa A, McMurray D, Ficht TA, de Figueiredo P. The Case for Live Attenuated Vaccines Against the Neglected Zoonotic Diseases Brucellosis and Bovine Tuberculosis. PLoS Neglected Tropical Diseases. 2016. Aug 18;10(8):e0004572. doi: 10.1371/journal.pntd.0004572. eCollection 2016 Aug. PMID: 27537413

Dickman MB and de Figueiredo P. Death Be Not Proud-Cell Death Control in Plant Fungal Interactions. PLoS Pathogens. 9(9): e1003542. doi:10.1371/journal.ppat.1003542. PMID: 24068920

Criscitiello MF, Dickman MB, Samuel JE, de Figueiredo P. Tripping on acid: trans-Kingdom perspectives on biological acids in immunity and pathogenesis. PLoS Pathogens. 2013. 9(7): e1003402. doi:10.1371/journal.ppat.1003402. PMID: 23874196

Han A, Hou H, Li L, Kim HS, de Figueiredo P. Microfabricated devices in microbial bioenergy sciences. Trends in Biotechnology. 2013. pii: S0167-7799(12)00221-1. PMID: 23453527

Criscitiello M and de Figueiredo P. Fifty shades of immune defense. PLoS Pathogens. 2013. 9(2): e1003110. doi:10.1371/journal.ppat.1003110 PMID: 23408882

Dickman MB and de Figueiredo P. Comparative pathobiology of pathogenic fungi of plants and animals. PLoS Pathogens. 2011. December; 7(12): e1002324. PMID: 22194681

Qin QM, Luo J, Lin X, Pei J, Li L, Ficht TA, de Figueiredo P. Functional analysis of host factors that mediate Cryptococcus neoformans intracellular trafficking. PLoS Pathogens. 2011. Jun;7(6):e1002078. Epub 2011 Jun 16. PMID: 21698225

Jupiter DC, Ficht TA, Samuel J, Qin QM, de Figueiredo P. DNA watermarking of infectious agents: progress and prospects. PLoS Pathogens. 2010. June 17;6(6):e1000950. PMID: 20585560

Qin QM, Pei J, Ancona V, Shaw BD, Ficht TA, de Figueiredo P. RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1a in supporting Brucella replication. PLoS Pathogens. 2008. July 25;4(7):e1000110 PMID: 1865462